Gene information
Official symbol C4A
Official full name complement C4A (Rodgers blood group)
Gene type protein-coding gene
Chromosome6p21.33
Alias symbolCPAMD2; C4S; CO4; C4; C4A3; C4A2; C4A4; C4A6; C4B; RG
Gene familyBlood group antigens; C3 and PZP like, alpha-2-macroglobulin domain containing; Complement system activation components
Resources
Entrez Gene 720
HGNC HGNC:1323
Ensembl ENSG00000244731
Vega OTTHUMG00000031186
UCSC uc011iuc.3
GO terms: 37 records
GO Description Category LogP Number of genes Detail
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002253 activation of immune response GO Biological Processes -3.86084748 14 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002449 lymphocyte mediated immunity GO Biological Processes -8.72662877 18 More
GO:0002455 humoral immune response mediated by circulating immunoglobulin GO Biological Processes -5.71650362 10 More
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -11.9339394 22 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006956 complement activation GO Biological Processes -7.12107226 12 More
GO:0006958 complement activation, classical pathway GO Biological Processes -5.86439052 10 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0016064 immunoglobulin mediated immune response GO Biological Processes -6.28897630 13 More
GO:0019724 B cell mediated immunity GO Biological Processes -7.00231964 14 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0030424 axon GO Cellular Components -6.14132550 54 More
GO:0030425 dendrite GO Cellular Components -4.55233052 48 More
GO:0043025 neuronal cell body GO Cellular Components -9.18558636 52 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0044297 cell body GO Cellular Components -11.7206640 62 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0050764 regulation of phagocytosis GO Biological Processes -16.0793009 29 More
GO:0050766 positive regulation of phagocytosis GO Biological Processes -13.5971167 15 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:0072562 blood microparticle GO Cellular Components -39.0217600 39 More
GO:0097447 dendritic tree GO Cellular Components -4.82959150 49 More
GO:2000425 regulation of apoptotic cell clearance GO Biological Processes -5.24494293 4 More
KEGG pathways: 6 records
KEGG Description Category LogP Number of genes Detail
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa04936 Alcoholic liver disease KEGG Pathway -13.3477535 19 More
hsa05133 Pertussis KEGG Pathway -13.2270528 15 More
hsa05150 Staphylococcus aureus infection KEGG Pathway -9.38905356 13 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05322 Systemic lupus erythematosus KEGG Pathway -4.88971598 10 More
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
complement C4-A proteomics old myocardial infarction[diagnosis] old myocardial infarction Muscari A et al. Cardiology. 1995
complement C4-A proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Akhtar N et al. Heart Asia. 2012
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